Endocrine Abstracts

Background: TPTD treatment has been shown to reduce vertebral and non-vertebral fracture risk in postmenopausal osteoporosis efficiently. However, gains in bone mass achieved by this treatment are almost lost 2 years after cessation of treatment, unless consecutively followed by an antiresorptive treatment such as alendronate.Subjects and methods: In the present prospective randomised open-labelled study in 52 pmp women, we investigated the effect of eit...

Hypoparathyroidism is a disorder of mineral homoeostasis due to parathyroid hormone (PTH) deficiency. Conventional treatment with oral Ca and calcitriol may maintain serum Ca levels but does not replace other physiologic PTH effects. RACE is an ongoing open-label study of recombinant human PTH1-84 (rhPTH1-84) for hypoparathyroidism treatment in adults (ClinicalTrials.gov NCT01297309). Patients initially received rhPTH1-84 25 or 50 μg/day subcutaneously, with 25-μg in...

Introduction: Primary and secondary hyperparathyroidism may coexist unrelated to chronic nephropathy. It can occur more often than expected, especially in elderly population with malabsorption syndrome or /and liver diseases.Case report: A women 60 years of age was admitted to hospital due to long standing ostealgia. The primary hyperparathyroidism was suspected. The medical history presented recently diagnosed coeliac disease and cryptogenic hepatic cir...

Autoimmune hypothalamitis has been implicated in idiopathic central diabetes insipidus (DI) due to antibodies against vasopressin producing hypothalamic cells. Lymphocytic infiltration of hypothalamus has been reported in patients with lymphocytic hypophysitis (LH) manifesting as hypopituitarism with DI. These patients can also have other associated autoimmune diseases. Here, we report a case of a male patient who presented with headache, poor orientation, partial hypopituitar...

Background: Given the general lack of descriptive epidemiological studies on thyroid storm, we aimed to estimate the incidence rate and case fatality of thyroid storm in Germany based on a large claims database.Methods: Using the German Pharmacoepidemiological Research Database (GePaRD) we identified patients with at least one inpatient discharge diagnosis of thyroid storm (International Statistical Classification of Diseases and Related Health Problems,...

We present a case of fludrocortisone-induced hypomagnesaemia in a 27-year old female with Autoimmune Polyglandular Syndrome Type1, manifesting as adrenal insufficiency, hypothyroidism and hypoparathyroidism. Her medications were; Alfalcidol 4 mcg; Levothyroxine 100 mcg; Hydrocortisone 20 mg bid; Fludrocortisone 200 mcg mane and 100 mcg nocte. The nocturnal dose of fludrocortisone was started 4 months prior to her presentation. She presented with a history of abdominal pain and...

Objective: The majority of circulating testosterone is bound to sex hormone-binding globulin (SHBG), but also to albumin and cortisol-binding globulin. The remaining part is free-circulating testosterone unattached to serum proteins, which represents the active form of the hormone. A common measurement of the free testosterone is the calculated free testosterone index (FTI)=100*(total testosterone/SHBG). Testosterone is the principal male sex hormone and is involved in the reg...

Context: Reoperative surgery is the most efficient treatment of cervical persistent thyroid carcinoma. The extent of the surgery should be guided by the preoperative imaging findings, the primary surgery and the patient’s prognosis. However, there is no consensus concerning the optimal surgical strategy.Objective: Primary objective was to evaluate morbidity of a reoperative surgery. Secondary objectives were to evaluate performances of preoperative ...

In addition to its central role in the control of thyrocyte growth and function, the TSHR is expressed during the differentiation of mesenchymal precursors. To explore further, we have developed an in vitro model in which TSHR activation is achieved by introducing constitutively active (M453T, L629F) TSHR, using retroviral vectors.We aimed to investigate the effect of TSHR activation on body composition, via the production of TNFα and express...

Objectives: While evidence for an increased risk of hypertension in both overt hyperthyroidism and overt hypothyroidism is consistent, the relation between subclinical hyperthyroidism and blood pressure has not yet received sufficient attention. We aimed to investigate possible associations of decreased serum thyrotropin levels and subclinical hyperthyroidism with blood pressure, pulse pressure, and the risk of hypertension.Design: The population-based c...